Calcifying epithelial odontogenic tumor associated with the left mandibular first premolar: a case report and literature review

J Korean Assoc Oral Maxillofac Surg 2012;38:166-70) Calcifying epithelial odontogenic tumor (CEOT) is a rarely reported benign tumor, accounting for 0.4-3% of all odontogenic tumors. Approximately 150 cases have been reported in the literature between 1958 and 2003. The age range of CEOT varies from 8 to 92 years with mean of 36.9 years, and the occurrence of the lesion in both genders is almost equal. It has 2 clinico-topographic variants: the intraosseous (94%) and the extraosseous (6%) type. The intraosseous type has a predilection for mandible (maxilla : mandible ratio of 1 : 2). The intraosseous CEOT commonly associated with non-erupted teeth accounts for more than half (52%) of the cases and usually appears as painless swelling that causes bony expansion. The location of diffused round-shaped calcifying material is inside the connective tissue stroma and epithelial islands. The tumors tend to be located toward the tooth crown, which usually has a unilocular radiolucent region containing variant radiopaque materials radiologically. In this paper, we report a case of CEOT occurring in the left mandibular first premolar of a 23-year-old female and present a brief review of the literature. Key word: Calcifying epithelial odontogenic tumor [paper submitted 2011. 8. 7 / revised 2011. 10. 13 / accepted 2011. 10. 15] times higher than that of the premolar region. About 52% of intraosseous CEOT usually appears in association with nonerupted or impacted teeth and as a painless swelling mass with cortical bone expansion. It has biological properties similar to those of intraosseous ameloblastoma and normally occurs in the reduced enamel epithelium on the dental lamina remnants and tooth crown. As for the differences between CEOT and ameloblastoma, the epithelial cells do not look like ameloblast, and the location of diffused roundshaped calcifying material is inside the connective tissue stroma and epithelial islands. The tumors tend to be located toward the crown of non-erupted teeth, which usually has a unilocular radiolucent region containing variant radiopaque materials radiologically. CEOT contains calcifying masses or homogenous non-cellular material within the tumor epithelium and stroma. In this paper, we report a case of CEOT occurring in the left mandibular first premolar of a 23-yearold female patient and present a brief review of the literature.